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Newcastle Disease ND is a viral disease spread worldwide with a high impact on economy and animal welfare. Vaccination against Newcastle Disease is one of the main control measures in countries such as Germany with endemic occurrence of Newcastle Disease virus in the free ranging bird population. However, it is still common practice to revaccinate only every twelve weeks because the SPCs of former vaccines proposed a revaccination after checking the antibody titer which based on practical knowledge was typically sufficient for twelve weeks.
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Background: Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis IPF and offers a beneficial risk-benefit profile. However, there are several other, progressive fibrotic lung diseases, in which conventional anti-inflammatory therapy is not sufficiently effective and antifibrotic therapies may offer a novel treatment option. Absolute change in percent predicted FVC from baseline – analyzed using a rank analysis of covariance ANCOVA model – will serve as efficacy-related primary study endpoint.
Discussion: There is an urgent unmet clinical need for effective therapies for patients with a progressive fibrotic lung disease other than IPF. The current study protocol is unique with respect to selecting patients with different disease entities of lung fibrosis which have, however, essential pathophysiological characteristics in common. Moreover, by selecting patients with evidence of disease progression despite conventional therapy, the protocol ensures that a cohort of interstitial lung disease ILD patients with a high unmet medical need is targeted and it may allow a sufficiently high event rate for evaluation of treatment responses.
Abstract Background: Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis IPF and offers a beneficial risk-benefit profile.
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Landhaus am Giessen, Vaduz, Cozy two-star hotel in Vaduz with a delicious breakfast buffet. Preferred date. Number of nights. Number of adults. Number of.
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To browse Academia. Skip to main content. Log In Sign Up. Add Social Profiles Facebook, Twitter, etc. Unfollow Follow Unblock. Other Affiliations:. Her university teaching profile includes linguistic Turcology, Balkan Turkish, Turkish Language and Culture in the Eastern Mediterranean Region, the Gagauz language and methods of linguistic fieldwork. She has conducted extensive fieldwork on previous undescribed linguistic varieties of Western Thrace Turkish and specialises in descriptive and contrastive analysis.
Her main focus is on Balkan Turkish, language contact and language variation. Her research area embraces also Turkish argot and semantics. Her interdisciplinary research interest revolves around language as complex set of linguistic varieties and social identity.
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CHF 44’CHF 36′ Kilometers. Power. benzin_mhev. Fuel. Automatic. Transmission. 08/ First Registration Date. More details. To the offer.
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